abstract：:A wealth of previous studies reported pathological alterations in extrahippocampal regions in mesial temporal lobe epilepsy. Previous experimental findings have also demonstrated that the entorhinal cortex and the neocortex are damaged in different animal models of acute limbic seizures. The present study was aimed at...

journal_title：Brain research bulletin

authors： Silva AV,Sanabria ER,Cavalheiro EA,Spreafico R

更新日期：2002-08-15 00:00:00

abstract：:We propose that separate sensory and hedonic representations exist in each of the primary structures of the somatosensory system, including brainstem, thalamic and cortical components. In the dorsal horn of the spinal cord, the hedonic representation, which consists primarily of nociceptive-specific, wide dynamic rang...

journal_title：Brain research bulletin

authors： Sewards TV,Sewards M

更新日期：2002-07-01 00:00:00

abstract：:The effects of intraseptally microinjected muscarinic (atropine sulfate, pirenzepine and gallamine) and nicotinic (hexamethonium) antagonists on spontaneous, sensory and electrically-induced hippocampal (HPC) theta EEG activity were investigated in the freely behaving cat. Administration of hexamethonium failed to eli...

journal_title：Brain research bulletin

authors： Gołebiewski H,Eckersdorf B,Konopacki J

更新日期：2002-07-01 00:00:00

abstract：:The C57BL/6J (B6) inbred mouse strain was compared to the A/J inbred strain for motor activity in an open-field, exploration of a hole-board, motor coordination in the coat-hanger test, and spatial learning in the Morris water maze. B6 mice displayed a higher number of segment crossings in the open-field and of hole-p...

journal_title：Brain research bulletin

authors： Thifault S,Lalonde R,Sanon N,Hamet P

更新日期：2002-06-01 00:00:00

abstract：:Chemical preconditioning using the mitochondrial toxin, 3-nitropropionic acid (3-NP) has been reported to induce neuroprotection against subsequent global ischemia. To investigate the underlying mechanisms, Mongolian gerbils were pretreated with either vehicle or 3-NP at the dose of 3 or 10 mg/kg, intraperitoneal, 3 d...

journal_title：Brain research bulletin

authors： Garnier P,Bertrand N,Demougeot C,Prigent-Tessier A,Marie C,Beley A

更新日期：2002-05-01 00:00:00

abstract：:The two experiments of the present study examined the influence of bilateral electrophysiologically-guided ibotenic acid lesions of the medial (gustatory) and lateral (viscerosensory) subdivisions of the parabrachial nucleus (PBN) on lipoprivic feeding and on the acquisition of a conditioned taste aversion. In Experim...

journal_title：Brain research bulletin

authors： Trifunovic R,Reilly S

更新日期：2002-05-01 00:00:00

abstract：:The discovery of spontaneous neuronal replacement in the adult vertebrate brain has changed the way in which we think about the biology of memory. This is because neuronal replacement is likely to have an impact on what a brain remembers and what it learns. Neuronal replacement has also changed the way in which we go ...

journal_title：Brain research bulletin

authors： Nottebohm F

更新日期：2002-04-01 00:00:00

abstract：:Although originally developed as a research tool for studying glial-glial and glial-axonal interactions, the technique of transplanting glial cell into the central nervous system has more recently been employed as a potential means for repairing persistent demyelination in clinical disease. It has now been clearly est...

journal_title：Brain research bulletin

authors： Franklin RJ

更新日期：2002-04-01 00:00:00

abstract：:We have examined the effects of the presence of the mutated human presenilin 1 gene (M146L; hps1*) on lesion-induced sprouting in the hippocampus of the mouse (C57/CBA). The entorhinal cortex was unilaterally lesioned with ibotenic acid in adult, male mice. Four weeks later the subsequent axonal sprouting in the denta...

journal_title：Brain research bulletin

authors： Kadish I,Pradier L,van Groen T

更新日期：2002-03-15 00:00:00

abstract：:We have studied the effects of 14-methoxymetopon (HS 198), a potent opioid agonist, on the responses to the tail electric stimulation test and plus-maze activity of adult male rats. The prototype mu agonist morphine was used as the drug of reference. Besides we addressed the effects of HS 198 on the serum corticostero...

journal_title：Brain research bulletin

authors： Urigüen L,Fernández B,Romero EM,De Pedro N,Delgado MJ,Guaza C,Schmidhammer H,Viveros MP

更新日期：2002-03-15 00:00:00

abstract：:The vertebrate neural tube consists of a series of neuromeres along its anteroposterior axis. Between amphioxus that possesses no neuromeres and gnathostomes, the lamprey occupies a critical position in the phylogeny for the origin of the segmented brain. To clarify the rhombomeric configuration of the Japanese lampre...

journal_title：Brain research bulletin

authors： Murakami Y,Ogasawara M,Satoh N,Sugahara F,Myojin M,Hirano S,Kuratani S

更新日期：2002-02-01 00:00:00

abstract：:Neurobiotin and Lucifer yellow, indicators of gap junctional coupling, were applied to primary afferent fibers of the frog. Following application of tracers to cervical or lumbar dorsal root fibers, a large number of labeled granule cells were detected in the corpus cerebelli, the brainstem, and the spinal cord. The v...

journal_title：Brain research bulletin

authors： Bácskai T,Matesz C

更新日期：2002-02-01 00:00:00

abstract：:An improved comparative interpretation of the teleostean forebrain suggests that the dorsal tier (Vd,Vc) and ventral tier (Vv,Vl) nuclei of the ventral telencephalic area (subpallium) represent the striatum and septum, respectively. Among other arguments, a dopaminergic innervation originating in the diencephalic post...

journal_title：Brain research bulletin

authors： Wullimann MF,Rink E

更新日期：2002-02-01 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) is the neuropeptide that links the brain to the reproductive system. Most vertebrate species express two forms of GnRH, which differ in amino acid sequence, localization, distribution, and embryological origin. The GnRH system in the ventral forebrain produces a species-specific G...

journal_title：Brain research bulletin

authors： Dubois EA,Zandbergen MA,Peute J,Goos HJ

更新日期：2002-02-01 00:00:00

abstract：:The expression of ErbB4 mRNA was examined in dorsal thalamic regions of chicks and rats. In rats, ErbB4 expression was observed in the habenular nuclei, the paraventricular nucleus, intermediodorsal nucleus, the central medial thalamic nucleus, the posterior nucleus, the parafascicular nucleus, the subparafascicular n...

journal_title：Brain research bulletin

authors： Bruce LL,Kornblum HI,Seroogy KB

更新日期：2002-02-01 00:00:00

abstract：:This study is a summary of investigations in the last decade with several collaborators on representatives of different vertebrate stocks. The results suggest that in the main vertebrate stocks (Agnathi, Chondrichthyes, Actinopterygii, Sarcopterygii-Amniotes), which had their parallel brain evolutions from the laminar...

journal_title：Brain research bulletin

authors： Kálmán M

更新日期：2002-02-01 00:00:00

abstract：:It is known that the pituitary-adrenal responses to lipopolysaccharide and interleukin (IL)-1 are sexually dimorphic in rodents, with females having an enhanced secretion of adrenocorticotropin (ACTH) and corticosterone. This study investigated whether the ACTH and corticosterone responses to tumor necrosis factor (TN...

journal_title：Brain research bulletin

authors： Watanobe H

更新日期：2002-01-15 00:00:00

abstract：:Blood-brain barrier permeability (BBB) to the inhibitory neurotransmitter gamma-amino butyric acid (GABA) was studied in rats following intraperitoneal (i.p) injections of GABA alone and in combination with L-Arginine (L-Arg). Administration of GABA (600 mg/kg body weight [b. wt.]) alone increased brain GABA concentra...

journal_title：Brain research bulletin

authors： Shyamaladevi N,Jayakumar AR,Sujatha R,Paul V,Subramanian EH

更新日期：2002-01-15 00:00:00

abstract：:In humans, perturbations in the developmental neuronal death leading to an excess of neurons could be associated with developmental neuropsychiatric disorders. Hu-bcl-2 transgenic mice appear to be a valuable tool to study the functional role of developmental programmed cell death. Indeed, the over-expression of the a...

journal_title：Brain research bulletin

authors： Rondi-Reig L,Mariani J

更新日期：2002-01-01 00:00:00

abstract：:There have been studies of the discriminative effects of intracerebroventricularly (ICV)-administered morphine (MOR) in rats trained to discriminate MOR systemically, but the converse has not been done. In this study, rats were trained to discriminate between ICV (1-10 microg/3 microl, 1 h) or subcutaneous (SC) (3.0 m...

journal_title：Brain research bulletin

authors： Easterling KW,Holtzman SG

更新日期：2001-12-01 00:00:00

abstract：:The availability of mutant mice that lack either MAO A or MAO B has created unique profiles in the central and peripheral availability of serotonin, norepinephrine, dopamine, and phenylethylamine. This paper summarizes some of the current known phenotypic findings in MAO A knock-out mice and contrast these with those ...

journal_title：Brain research bulletin

authors： Holschneider DP,Chen K,Seif I,Shih JC

更新日期：2001-11-15 00:00:00

abstract：:Ten years after the discovery of human diseases caused by trinucleotide repeat expansions, searching for mechanistic links between gene mutation and pathological phenotype remains a fundamental and unsolved issue. Evidence accumulated so far indicates that the pathogenesis of repeat disorders is complex and multi-fact...

journal_title：Brain research bulletin

authors： Galvão R,Mendes-Soares L,Câmara J,Jaco I,Carmo-Fonseca M

更新日期：2001-10-01 00:00:00

abstract：:Simple tandem repeats represent more than 1% of the human genome: occasionally they exhibit intergenerational expansibility and are associated with neuromuscular diseases. In transgenic mice the same sequences elicit similar symptoms, but do not expand. We have searched for di-, tri-, and tetra-repeats in the publishe...

journal_title：Brain research bulletin

authors： Astolfi P,Bellizzi D,Losso MA,Sgaramella V

更新日期：2001-10-01 00:00:00

abstract：:Spinocerebellar ataxia type 2 is caused by a polyglutamine stretch in the protein ataxin-2 that is due to an expansion of a CAG repeat in the spinocerebellar ataxia-2 gene. The function of wild-type ataxin-2 has not been clarified. A widespread distribution of this protein throughout the brain has been reported. We ex...

journal_title：Brain research bulletin

authors： Fusco FR,Viscomi MT,Bernardi G,Molinari M

更新日期：2001-10-01 00:00:00

abstract：:Microtubule associated proteins are a heterogeneous group of proteins that have been implicated in regulating microtubule stability. They play an important role in the organisation of the neuronal cytoskeleton during neurite outgrowth, plasticity and regeneration. The fish visual system presents a considerable degree ...

journal_title：Brain research bulletin

authors： Vecino E,Avila J

更新日期：2001-09-15 00:00:00

abstract：:The roles of prostaglandins (PGs) involved in opioidergic, cholinergic, and serotonergic regulation of the diurnal changes of tuberoinfundibular dopaminergic (TIDA) neuronal activities were investigated in ovariectomized, estrogen-treated rats. Treatment with naloxone [10 mg/kg, intraperitoneal (i.p.)], atropine (5 mg...

journal_title：Brain research bulletin

authors： Chu YC,Tsou MY,Pan JT

更新日期：2001-09-01 00:00:00

abstract：:Endogenous adrenergic drive regulates the firing rate of serotonergic neurons. However, advocates of feedback theory assert that 5-hydroxytryptamine (5-HT) released in the somatodendritic region of raphe neurons regulates both rate and release of 5-HT. Experiments were done to determine if the somatodendritic region m...

journal_title：Brain research bulletin

authors： Kalsner S,Abdali SA

更新日期：2001-08-01 00:00:00

abstract：:Abnormalities of the ionotropic glutamate receptors (N-methyl-D-aspartate, alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid [AMPA], and kainate) have been reported in the brain in schizophrenia, although in complex, region-specific patterns. While limbic cortex and medial temporal lobe structures have been mo...

journal_title：Brain research bulletin

authors： Meador-Woodruff JH,Hogg AJ Jr,Smith RE

更新日期：2001-07-15 00:00:00

abstract：:Ongoing maternal behavior in rats is under the inhibitory influence of opiates. Exposure to drugs of abuse may result in a progressive and enduring enhancement of their reinforcing effects. Little attention has been paid to the possibility that puerperal treatment with morphine may lead to sensitization to this drug, ...

journal_title：Brain research bulletin

authors： Miranda-Paiva CM,Nasello AG,Yin AJ,Felicio LF

更新日期：2001-07-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) is considered a major inhibitory neurotransmitter in the generation of presynaptic inhibition at central terminals of primary afferent fiber (PAF), while it has also been established that nitric oxide (NO) may sensitize the terminals of nocisponsive PAFs and enhance neuropeptide release,...

journal_title：Brain research bulletin

authors： Bie BH,Zhao ZQ

更新日期：2001-06-01 00:00:00

abstract：:In order to study mechanisms by which a neurotropic strain of influenza A virus (A/WSN/33) may affect neuronal function or cause nerve cell death, hippocampal cultures from embryonic rats were infected with this virus. Approximately 70% of the neurons in the infected cultures became immunopositive for viral antigens a...

journal_title：Brain research bulletin

authors： Brask J,Owe-Larsson B,Hill RH,Kristensson K

更新日期：2001-06-01 00:00:00

abstract：:Metallothioneins (MTs) (I+II) play pivotal roles in metal-related cell homeostasis because of their high affinity for metals forming clusters. The main functional role of MTs is to sequester and/or dispense zinc participating in zinc homeostasis. Consistent with this role, MT gene expression is transcriptionally induc...

journal_title：Brain research bulletin

authors： Mocchegiani E,Giacconi R,Cipriano C,Muzzioli M,Fattoretti P,Bertoni-Freddari C,Isani G,Zambenedetti P,Zatta P

更新日期：2001-05-15 00:00:00

abstract：:Aluminium is highly neurotoxic and inhibits prenatal and postnatal development of the brain in humans and experimental animals. However, the incorporation of aluminium into the brain of fetuses and sucklings during gestation and lactation has not been well clarified because aluminium lacks a suitable isotope for a tra...

journal_title：Brain research bulletin

authors： Yumoto S,Nagai H,Matsuzaki H,Matsumura H,Tada W,Nagatsuma E,Kobayashi K

更新日期：2001-05-15 00:00:00

abstract：:The effects of zinc, the N-methyl-D-aspartate glutamate receptor inhibitor, were studied in mice and rats using the forced swim test. Zinc (ZnSO4) in a dose of 30 mg/kg and imipramine (30 mg/kg), reduced the immobility time in the forced swim test in both species. Moreover, combined treatment in this test with zinc an...

journal_title：Brain research bulletin

authors： Kroczka B,Branski P,Palucha A,Pilc A,Nowak G

更新日期：2001-05-15 00:00:00

abstract：:Neonatal hippocampal lesions in rats produce behavioral and neurochemical abnormalities post-puberty that are used in animal models for developmentally linked pathology in schizophrenia. In one model, adult rats exhibit enhanced sensitivity to the locomotor-activating effects of amphetamine, if they had sustained exci...

journal_title：Brain research bulletin

authors： Swerdlow NR,Halim N,Hanlon FM,Platten A,Auerbach PP

更新日期：2001-05-01 00:00:00

abstract：:It is known that spinal nociceptive sensory transmission receives descending inhibitory and facilitatory modulation from supraspinal structures. Glutamate is the major fast excitatory transmitter between primary afferent fibers and spinal dorsal horn neurons. In whole-cell patch clamp recordings from dorsal horn neuro...

journal_title：Brain research bulletin

authors： Li P,Zhuo M

更新日期：2001-04-01 00:00:00

abstract：:We examined effects of omega-conotoxin previously known as a selective blocker of N-type calcium channels, on the adenosine triphosphate (ATP)-induced currents in the rat dorsal root ganglion neurons. These neurons express at least two types of ionotropic purinoreceptors: P2X3 receptors that have very rapid desensitiz...

journal_title：Brain research bulletin

authors： Lalo UV,Pankratov YV,Arndts D,Krishtal OA

更新日期：2001-03-15 00:00:00

abstract：:The pattern of NADPH-diaphorase expression was studied in the retina and optic tectum of the cichlid fish Tilapia mariae during the first developmental stages. NADPH-diaphorase activity was seen early, at hatching. In the retina a few cell bodies of the retinal inner nuclear layer showed a faint labeling. Scattered la...

journal_title：Brain research bulletin

authors： Villani L,Minelli D,Giuliani A,Quaglia A

更新日期：2001-03-15 00:00:00

abstract：:The present study examined the changes of extracellular concentration of dopamine and its metabolite homovanillic acid in the striatum, the periaqueductal gray and the dorsal horn of lumbar spinal cord following intraplantar injection of carrageenan. In vivo microdialysis and high-performance liquid chromatography wit...

journal_title：Brain research bulletin

authors： Gao X,Zhang YQ,Zhang LM,Wu GC

更新日期：2001-03-01 00:00:00

abstract：:This review focuses on the maturation of brain white-matter, as revealed by magnetic resonance (MR) imaging carried out in healthy subjects. The review begins with a brief description of the nature of the MR signal and its possible biological underpinnings, and proceeds with a description of MR findings obtained in ne...

journal_title：Brain research bulletin

authors： Paus T,Collins DL,Evans AC,Leonard G,Pike B,Zijdenbos A

更新日期：2001-02-01 00:00:00